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Form	MW
1-(1-Naphthyl)piperazine This page	212.29
1-(1-Naphthyl)piperazine hydrochloride	248.75

1-(1-Naphthyl)piperazine

5-HT Receptor Modulator

1-(1-Naphthyl)piperazine is a modulator of the 5-HT receptors, functioning as an antagonist at the 5-HT2A receptor and an agonist at the 5-HT1A receptor. It demonstrates a binding affinity for the human 5-HT6 receptor with a Ki value of 120 nM. Additionally, 1-(1-Naphthyl)piperazine has been shown to inhibit forskolin-stimulated adenylate cyclase activity in calf substantia nigra, and it mitigates UV-induced immunosuppression. This compound induces S-phase cell cycle delay and apoptosis while elevating ROS levels, ultimately leading to the inhibition of MNT-1 cell proliferation, making it a valuable tool for melanoma research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	57536-86-4
Applications	5-HT Receptor Modulator
Formula	C₁₄H₁₆N₂
Molecular Weight	212.29
SMILES	C12=C(C=CC=C2N3CCNCC3)C=CC=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.