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1,2-Di-O-acetyl-3-azido-3-deoxy-5-O-(4-methyl)benzoyl-D-ribofuranose

Purine Nucleoside Analog

1,2-Di-O-acetyl-3-azido-3-deoxy-5-O-(4-methyl)benzoyl-D-ribofuranose is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptotic pathways. Additionally, this compound serves as a versatile click chemistry reagent, thanks to its azide functionality, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This dual utility broadens its applicability in chemical biology and medicinal chemistry research.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	120143-22-8
Applications	Purine Nucleoside Analog
Formula	C₁₇H₁₉N₃O₇
Molecular Weight	377.35
SMILES	[N-]=[N+]=N[C@H]1[C@@H](OC(C)=O)C(OC(C)=O)O[C@@H]1COC(C2=CC=C(C)C=C2)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.