Fig. 1 · Structure
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1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one
Antiviral Activity
1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one is a potent inhibitor of the nucleocapsid (N) protein, derived from Curcuma kwangsiensis. This compound demonstrates significant antiviral activity, effectively targeting human coronavirus strains such as HCoV-OC43 and SARS-CoV-2, with EC50 values of 0.16 μM and 0.17 μM, respectively. It is valuable for research into antiviral therapeutics and mechanisms of viral replication.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 149732-52-5 |
| Applications | Antiviral Activity |
| Formula | C19H16O3 |
| Molecular Weight | 292.33 |
| SMILES | OC(C=C1)=CC=C1/C=C/C=C/C(/C=C/C2=CC=C(C=C2)O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.