1,8-Dihydroxy-4,5-dinitroanthraquinone is an effective inhibitor of the dengue viral serine proteinase NS2B/3. This compound demonstrates significant antiviral activity with an IC50 of 4.2 μM against viral replication, while also exhibiting proteinase inhibition with an IC50 of 432 μM. Additionally, 1,8-Dihydroxy-4,5-dinitroanthraquinone disrupts NS2B/3 cleavage in BHK-21 cells, providing a valuable tool for research into dengue virus mechanisms and potential therapeutic strategies.
1,8-Dihydroxy-4,5-dinitroanthraquinone is an effective inhibitor of the dengue viral serine proteinase NS2B/3. This compound demonstrates significant antiviral activity with an IC50 of 4.2 μM against viral replication, while also exhibiting proteinase inhibition with an IC50 of 432 μM. Additionally, 1,8-Dihydroxy-4,5-dinitroanthraquinone disrupts NS2B/3 cleavage in BHK-21 cells, providing a valuable tool for research into dengue virus mechanisms and potential therapeutic strategies.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
