Fig. 1 · Structure
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PE
Phospholipid
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE is a phosphatidylethanolamine (PE) lipid that targets lipid bilayers to facilitate the formation of hexagonal phase (HII) structures in acidic environments and promote membrane fusion. Its primary biological activity includes enhancing the endosomal escape of lipid nanoparticles (LNPs), thereby improving the delivery efficiency of nucleic acid therapeutics such as mRNA. This compound is particularly valuable in research applications focused on gene therapy and the development of mRNA vaccines, serving as an effective LNP carrier for targeted cellular delivery.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 26662-94-2 |
| Applications | Phospholipid |
| Formula | C39H76NO8P |
| Molecular Weight | 718.00 |
| Synonyms | 1,2-POPE; 16:0-18:1 PE |
| SMILES | CCCCCCCC/C=C\CCCCCCCC(O[C@@H](COP(O)(OCCN)=O)COC(CCCCCCCCCCCCCCC)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.