Fig. 1 · Structure
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1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine
Phospholipids
1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine is a phospholipid featuring stearic acid and oleic acid at the sn-1 and sn-2 positions, respectively. This compound plays a critical role in the formulation of lipid nanoparticles (LNPs), facilitating efficient in vitro delivery of mRNA and nuclear-targeted plasmid DNA. Its unique fatty acid composition enhances membrane fluidity and stability, making it invaluable in gene therapy and vaccine research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 6418-95-7 |
| Applications | Phospholipids |
| Formula | C41H80NO8P |
| Molecular Weight | 746.05 |
| Synonyms | 1-Stearoyl-2-Oleoyl-sn-glycero-3-PE; 18:0-18:1 PE; PE(18:0/18:1) |
| SMILES | CCCCCCCC/C=C\CCCCCCCC(O[C@@H](COP(O)(OCCN)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.