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10-Butyl Ether Minocycline

MMP-8/9 Inhibitor

10-Butyl Ether Minocycline is a derivative of Minocycline that functions as an inhibitor of matrix metalloproteinases MMP-8 and MMP-9, exhibiting IC50 values of 69.4 µM and 47.0 µM, respectively. This compound effectively suppresses lipopolysaccharide-induced microglial activation, inhibits VEGF-induced endothelial cell migration, and reduces L-Glutamine-induced reactive oxygen species levels. Additionally, 10-Butyl Ether Minocycline is shown to significantly decrease alcohol consumption in the Chronic Intermittent Ethanol mouse model of alcohol dependence, making it a valuable reagent for research into neuroimmune-inflammatory diseases and alcohol use disorder.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	488815-65-2
Applications	MMP-8/9 Inhibitor
Formula	C₂₇H₃₅N₃O₇
Molecular Weight	513.58
Synonyms	BEM
SMILES	[H][C@@]12C[C@@]3(CC4=C(C=CC(OCCCC)=C4C(C3=C([C@@]1(C(C(C(N)=O)=C([C@H]2N(C)C)O)=O)O)O)=O)N(C)C)[H]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.