Fig. 1 · Structure
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10-Methoxy-canthin-6-one
DNA Damage Inducer
10-Methoxy-canthin-6-one is an alkaloid derivative that serves as a DNA damage inducer by intercalating into DNA. It exhibits significant biological activity by inhibiting cancer cell proliferation, causing G2/M phase arrest, and promoting myeloid differentiation. Additionally, 10-methoxy-canthin-6-one upregulates the expression of myeloperoxidase, CD15, CD11b, and CD14 while activating the p38 MAPK pathway. Its anti-bacterial properties further expand its research applications, particularly in studies related to cancer and infections, including acute myeloid leukemias (AML).
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 86293-40-5 |
| Applications | DNA Damage Inducer |
| Formula | C15H10N2O2 |
| Molecular Weight | 250.25 |
| Synonyms | Mtx-C |
| SMILES | O=C1C=CC2=NC=CC3=C2N1C4=CC=C(OC)C=C34 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.