Fig. 1 · Structure
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12(R)-HETE
TP Receptor Antagonist
12(R)-HETE is a thromboxane A2 (TP) receptor antagonist that modulates proinflammatory signaling pathways. This CYP-dependent metabolite of arachidonic acid exhibits multiple biological activities, including chemotaxis, proangiogenesis, vasodilation, and reduction of intraocular pressure. Its ability to inhibit Na+,K+-ATPase activity and block intracellular calcium increases induced by TP agonists further adds to its relevance in research. 12(R)-HETE is useful in studies focused on psoriasis, inflammatory skin diseases, and ocular inflammation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 82337-46-0 |
| Applications | TP Receptor Antagonist |
| Formula | C20H32O3 |
| Molecular Weight | 320.47 |
| SMILES | CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(O)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.