Fig. 1 · Structure
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15-deoxy-Δ12,14-Prostaglandin D2
Prostaglandin Receptor Agonist
15-deoxy-Δ12,14-Prostaglandin D2 is a potent agonist of the prostaglandin receptor 2 (DP2), demonstrating a binding affinity with a Ki value of 50 nM. It elicits eosinophil activation with an EC50 of 8 nM and facilitates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), promoting PPARγ-mediated transcription. Additionally, this compound exhibits cytotoxic effects on L1210 murine leukemia cells (IC50 of 0.3 μg/ml) and inhibits ADP-induced platelet aggregation (IC50 of 320 ng/mL), making it relevant for research in inflammation and cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 85235-11-6 |
| Applications | Prostaglandin Receptor Agonist |
| Formula | C20H30O4 |
| Molecular Weight | 334.45 |
| Synonyms | 15-Deoxy-Δ12,14-PGD2 |
| SMILES | O=C1/C([C@H]([C@H](C1)O)C/C=C\CCCC(O)=O)=C/C=C/CCCCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.