15-keto-Prostaglandin E2 is a metabolite of prostaglandin E2 that primarily targets and inhibits STAT3 activation through binding to the Cys259 residue. This compound has been shown to inhibit the growth and progression of breast cancer cells while activating PPAR-γ, promoting fungal growth. Additionally, 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development, resulting in a decreased surface area of the glomerular filtration barrier, highlighting its importance in developmental biology and cancer research.
15-keto-Prostaglandin E2 is a metabolite of prostaglandin E2 that primarily targets and inhibits STAT3 activation through binding to the Cys259 residue. This compound has been shown to inhibit the growth and progression of breast cancer cells while activating PPAR-γ, promoting fungal growth. Additionally, 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development, resulting in a decreased surface area of the glomerular filtration barrier, highlighting its importance in developmental biology and cancer research.
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