15(S)-HETRE is a lipoxygenase inhibitor, specifically targeting 5-lipoxygenase (5-LO) derived from dihomo-γ-linolenic acid through 15-lipoxygenation. It demonstrates significant inhibitory activity in human polymorphonuclear leukocytes (PMNL) with an IC50 of 4.6 μM. Additionally, in rat basophilic leukemia (RBL) cells, 15(S)-HETRE effectively inhibits 5-LO, albeit with approximately one-twentieth the potency compared to 15(S)-HpETE. This compound is utilized in research applications focused on inflammatory processes and leukotriene synthesis.
15(S)-HETRE is a lipoxygenase inhibitor, specifically targeting 5-lipoxygenase (5-LO) derived from dihomo-γ-linolenic acid through 15-lipoxygenation. It demonstrates significant inhibitory activity in human polymorphonuclear leukocytes (PMNL) with an IC50 of 4.6 μM. Additionally, in rat basophilic leukemia (RBL) cells, 15(S)-HETRE effectively inhibits 5-LO, albeit with approximately one-twentieth the potency compared to 15(S)-HpETE. This compound is utilized in research applications focused on inflammatory processes and leukotriene synthesis.
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