Fig. 1 · Structure
Documents & Downloads
15(S)-HETRE
Cat. No.
A76440
CAS
92693-02-2
Lipoxygenase Inhibitor
15(S)-HETRE is a lipoxygenase inhibitor, specifically targeting 5-lipoxygenase (5-LO) derived from dihomo-γ-linolenic acid through 15-lipoxygenation. It demonstrates significant inhibitory activity in human polymorphonuclear leukocytes (PMNL) with an IC50 of 4.6 μM. Additionally, in rat basophilic leukemia (RBL) cells, 15(S)-HETRE effectively inhibits 5-LO, albeit with approximately one-twentieth the potency compared to 15(S)-HpETE. This compound is utilized in research applications focused on inflammatory processes and leukotriene synthesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 92693-02-2 |
| Applications | Lipoxygenase Inhibitor |
| Formula | C20H34O3 |
| Molecular Weight | 322.48 |
| SMILES | CCCCC[C@H](/C=C/C=C\C/C=C\CCCCCCC(O)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.