17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid serves as a PPARγ agonist, primarily impacting inflammatory processes. This electrophilic oxo-derivative of docosahexaenoic acid (DHA) is produced in activated macrophages through a COX-2-catalyzed mechanism during inflammation. Its biological activity includes modulation of the NF-κB signaling pathway, inhibition of pro-inflammatory cytokine production, and reduction of nitric oxide synthesis, demonstrating significant anti-inflammatory properties. This compound is particularly valuable for research applications focused on inflammatory diseases and metabolic disorders.
17-Oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid serves as a PPARγ agonist, primarily impacting inflammatory processes. This electrophilic oxo-derivative of docosahexaenoic acid (DHA) is produced in activated macrophages through a COX-2-catalyzed mechanism during inflammation. Its biological activity includes modulation of the NF-κB signaling pathway, inhibition of pro-inflammatory cytokine production, and reduction of nitric oxide synthesis, demonstrating significant anti-inflammatory properties. This compound is particularly valuable for research applications focused on inflammatory diseases and metabolic disorders.
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