(1α,1'S,4β)-Lanabecestat is the less active enantiomer of the BACE1 inhibitor, Lanabecestat. This compound exhibits effective inhibition of BACE1, a key enzyme involved in the amyloidogenic pathway associated with Alzheimer's disease. With a potent Ki of 0.4 nM for its active form, (1α,1'S,4β)-Lanabecestat serves as a valuable tool for research on Alzheimer's therapeutics and the role of BACE1 in neurodegenerative processes.
(1α,1'S,4β)-Lanabecestat is the less active enantiomer of the BACE1 inhibitor, Lanabecestat. This compound exhibits effective inhibition of BACE1, a key enzyme involved in the amyloidogenic pathway associated with Alzheimer's disease. With a potent Ki of 0.4 nM for its active form, (1α,1'S,4β)-Lanabecestat serves as a valuable tool for research on Alzheimer's therapeutics and the role of BACE1 in neurodegenerative processes.
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