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(1R,2S,3R)-Aprepitant

NK-1 Receptor Antagonist

(1R,2S,3R)-Aprepitant is a competitive antagonist of the human neurokinin-1 (NK-1) receptor. This compound exhibits significant potential in the study of conditions such as cancer and postoperative nausea and vomiting. Its ability to modulate NK-1 receptor activity makes it a valuable tool for research exploring therapeutic interventions in these areas.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	1185502-97-9
Applications	NK-1 Receptor Antagonist
Formula	C₂₃H₂₁F₇N₄O₃
Molecular Weight	534.43
SMILES	C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)O[C@H](OCC2)[C@@H](C3=CC=C(C=C3)F)N2CC4=NNC(N4)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.