Fig. 1 · Structure
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(1R)-BMS-986408
DGK Inhibitor
(1R)-BMS-986408 is an orally active dual inhibitor of diacylglycerol kinases (DGK) α and ζ. This compound enhances T cell signaling, thereby restoring T cell-mediated anti-tumor immunity. It serves as a valuable tool for research into cancer immunotherapy and the modulation of immune responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2618418-11-2 |
| Applications | DGK Inhibitor |
| Formula | C27H31F3N6O |
| Molecular Weight | 512.57 |
| SMILES | CC[C@H]1CN([C@@H](CN1C2=NC(N(C3=CC=C(N=C32)C#N)C)=O)CC)[C@@H](C4=CC=C(C=C4)C(F)(F)F)CC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.