Fig. 1 · Structure
Documents & Downloads
BMS-986408
DGKα/ζ Inhibitor
BMS-986408 is a potent inhibitor of diacylglycerol kinases alpha (DGKα) and zeta (DGKζ), exhibiting IC50 values of 0.0003 μM and 0.002 μM respectively. This compound enhances intratumoral T cell responses and promotes the priming and expansion of tumor-reactive T cells in tumor-draining lymph nodes, functioning as a valuable immunostimulant. BMS-986408 is useful for investigating tumor immunology and T cell activation in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2618418-12-3 |
| Applications | DGKα/ζ Inhibitor |
| Formula | C27H31F3N6O |
| Molecular Weight | 512.57 |
| SMILES | CC[C@H]1CN([C@@H](CN1C2=NC(N(C3=CC=C(N=C32)C#N)C)=O)CC)[C@H](C4=CC=C(C=C4)C(F)(F)F)CC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.