(1S,2R)-Alicapistat is a selective inhibitor of human calpains 1 and 2, targeting these proteolytic enzymes involved in cellular signaling. With an IC50 value of 395 nM for calpain 1, it demonstrates significant biological activity, potentially making it valuable in Alzheimer's disease research. This compound's oral bioavailability and specificity may aid in elucidating the role of calpains in neurodegenerative disorders.
(1S,2R)-Alicapistat is a selective inhibitor of human calpains 1 and 2, targeting these proteolytic enzymes involved in cellular signaling. With an IC50 value of 395 nM for calpain 1, it demonstrates significant biological activity, potentially making it valuable in Alzheimer's disease research. This compound's oral bioavailability and specificity may aid in elucidating the role of calpains in neurodegenerative disorders.
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