Fig. 1 · Structure
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(1S,2S)-ML-SI3
Cat. No.
A68723
CAS
2563870-87-9
TRPML2/3 Activator
(1S,2S)-ML-SI3 is a selective activator of the TRPML2 and TRPML3 isoforms, exhibiting EC50 values of 2.7 μM and 10.8 μM, respectively, while serving as a potent inhibitor of TRPML1 with an IC50 of 5.9 μM. This compound facilitates investigations into lysosomal ion channel functions, cellular ion homeostasis, and related signaling pathways. Its unique pharmacological profile makes it a valuable tool for researchers studying the role of TRPML channels in various biological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 2563870-87-9 |
| Applications | TRPML2/3 Activator |
| Formula | C23H31N3O3S |
| Molecular Weight | 429.58 |
| Synonyms | (+)-trans-ML-SI3 |
| SMILES | COC1=CC=CC=C1N2CCN([C@H]3CCCC[C@@H]3NS(C4=CC=CC=C4)(=O)=O)CC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.