(1S,2S)-ML-SI3 is a selective activator of the TRPML2 and TRPML3 isoforms, exhibiting EC50 values of 2.7 μM and 10.8 μM, respectively, while serving as a potent inhibitor of TRPML1 with an IC50 of 5.9 μM. This compound facilitates investigations into lysosomal ion channel functions, cellular ion homeostasis, and related signaling pathways. Its unique pharmacological profile makes it a valuable tool for researchers studying the role of TRPML channels in various biological processes.
(1S,2S)-ML-SI3 is a selective activator of the TRPML2 and TRPML3 isoforms, exhibiting EC50 values of 2.7 μM and 10.8 μM, respectively, while serving as a potent inhibitor of TRPML1 with an IC50 of 5.9 μM. This compound facilitates investigations into lysosomal ion channel functions, cellular ion homeostasis, and related signaling pathways. Its unique pharmacological profile makes it a valuable tool for researchers studying the role of TRPML channels in various biological processes.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
