Fig. 1 · Structure
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2-Amino-2-deoxyglucose hydrochloride
GLUT1 Substrate
2-Amino-2-deoxyglucose hydrochloride is a glucose analog that serves as a substrate for the GLUT1 transporter. It exhibits significant potential as a tumor-targeting ligand and a component in the fabrication of prodrug conjugates, facilitating targeted drug delivery to cancer cells. This reagent is valuable in diagnostic imaging and evaluating therapeutic outcomes in solid tumors, including breast cancer and glioblastoma. Additionally, it contributes to investigations into bacterial resistance mechanisms, particularly by incorporating into the peptidoglycan of Streptococcus pneumoniae, aiding in the evasion of lysozyme digestion. This compound is essential for research in tumor metabolism and antibiotic resistance studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 1078691-95-8 |
| Applications | GLUT1 Substrate |
| Formula | C6H14ClNO5 |
| Molecular Weight | 215.63 |
| Synonyms | D-Glucosamine Hydrochloride |
| SMILES | OC1[C@H](N)[C@H]([C@@H]([C@@H](CO)O1)O)O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.