Fig. 1 · Structure
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2-Aminobenzothiazole
Caspase 3/7 Activator
2-Aminobenzothiazole is a potent activator of caspase 3 and 7, functioning as an anticancer agent through its pro-apoptotic properties. This compound initiates the apoptotic cascade by promoting mitochondrial membrane depolarization, resulting in both early and late apoptosis via a caspase-dependent mechanism. In zebrafish models, 2-Aminobenzothiazole has been shown to induce oxidative damage in neuronal tissues while inhibiting genes involved in GABA and serotonin synthesis, leading to deficits in motor abilities, social interactions, and cognitive functions. Its applications extend to research on human laryngeal carcinoma and the investigation of neurotoxic effects.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 136-95-8 |
| Applications | Caspase 3/7 Activator |
| Formula | C7H6N2S |
| Molecular Weight | 150.21 |
| SMILES | NC1=NC2=CC=CC=C2S1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.