2-(Azido-PEG2-amido)-1,3-propandiol is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that allows for cupric ion-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its versatile reactivity makes it a valuable tool for bioconjugation and advanced chemical biology applications in drug discovery.
2-(Azido-PEG2-amido)-1,3-propandiol is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that allows for cupric ion-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its versatile reactivity makes it a valuable tool for bioconjugation and advanced chemical biology applications in drug discovery.
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