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2-Bromo-2,2-dimethyl-acetamido-PEG3-acid

PROTAC Linkers

2-Bromo-2,2-dimethyl-acetamido-PEG3-acid is a PEG-based linker designed specifically for the synthesis of PROTAC (Proteolysis Targeting Chimera) compounds. This linker facilitates the development of bifunctional molecules that can recruit E3 ubiquitin ligases for targeted protein degradation. Its application in research allows for innovative approaches to modulate protein levels and explore the therapeutic potential of targeted protein degradation strategies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2279944-67-9
Applications	PROTAC Linkers
Formula	C₁₃H₂₄BrNO₆
Molecular Weight	370.24
SMILES	OC(CCOCCOCCOCCNC(C(C)(C)Br)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.