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2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation. It is also inhibits Axl, IRAK4, ROS1, MLK4, GSK3β, RET, KDR and PI3Kα with IC50 values of 0.49, 3.9, 5.3, 9.8, 11, 11, 17 and 35 nM respectively in biochemical assays.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37 mL | 185.02 mL | 370.04 mL |
| 0.5 mM | 7.4 mL | 37 mL | 74.01 mL |
| 1 mM | 3.7 mL | 18.5 mL | 37 mL |
| 5 mM | 0.74 mL | 3.7 mL | 7.4 mL |
*The above data is based on the productmolecular weight 270.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16852 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 270.24 |
| Formula | C15H10O5 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 144707-18-6 |
| Synonyms | 2D08 |
| SMILES | O=C1C=C(C2=CC=C(O)C(O)=C2O)OC3=CC=CC=C13 |
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