2'-Deoxyadenosine monohydrate-5′-13C is a stable isotope-labeled form of 2'-Deoxyadenosine monohydrate, primarily targeting cellular metabolism and signaling pathways. This compound inhibits glucose-stimulated insulin release by blocking the increase of cyclic AMP (cAMP) in pancreatic islets and activating caspase-3, thereby promoting apoptosis. Additionally, it inhibits S-adenosyl-L-homocysteine hydrolase (SAHH) activity and demonstrates growth-inhibitory effects on various cell types, exhibiting potential anticancer properties, particularly against colon cancer. These characteristics make it a valuable tool for studies in metabolic regulation and cancer research.
2'-Deoxyadenosine monohydrate-5′-13C is a stable isotope-labeled form of 2'-Deoxyadenosine monohydrate, primarily targeting cellular metabolism and signaling pathways. This compound inhibits glucose-stimulated insulin release by blocking the increase of cyclic AMP (cAMP) in pancreatic islets and activating caspase-3, thereby promoting apoptosis. Additionally, it inhibits S-adenosyl-L-homocysteine hydrolase (SAHH) activity and demonstrates growth-inhibitory effects on various cell types, exhibiting potential anticancer properties, particularly against colon cancer. These characteristics make it a valuable tool for studies in metabolic regulation and cancer research.
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