Fig. 1 · Structure
Documents & Downloads
2-Guanidinobezimidazole
NLRP3 Selective Agonist
2-Guanidinobezimidazole is a selective agonist of the NLRP3 inflammasome, exhibiting a KD value of 1.29 μM towards His-GFP-NLRP3. By binding directly to the leucine-rich repeat (LRR) domain of NLRP3, it facilitates inflammasome assembly and activation. This compound is pertinent for research into anti-tumor immunity, demonstrating potential to inhibit tumor growth and address resistance to immune checkpoint blockade (ICB).
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 5418-95-1 |
| Applications | NLRP3 Selective Agonist |
| Formula | C8H9N5 |
| Molecular Weight | 175.19 |
| Synonyms | 2GBI |
| SMILES | N/C(N)=N/C1=NC2=CC=CC=C2N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.