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2-HBA

NQO1 inducer

2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.

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Biological Activity

Target & Activity

Target	Activity	Value
Caspase-3
Caspase-10

Cellular Effect

Cell Line	Activity	Value	Description	Reference
Ca-Ski	EC50	1.03 μM	Antiproliferative activity against human Ca-Ski cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 32172081]
HeLa	EC50	1.03 μM	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 32172081]
HeLa	EC50	2.6 μM	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 32172081]
HUVEC	GI50	1.8 μM	Cytotoxicity against HUVEC cells assessed as cell growth inhibition by anti-angiogenisis screening assay	[PMID: 32172081]
MDA-MB-231	GI50	1 μM	Growth inhibition of human MDA-MB-231 cells measured after 72 hrs by microplate reader analysis	[PMID: 32172081]
RAW264.7	IC50	10.24 μM	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma/LPS-stimulated nitric oxide production after 17 to 20 hrs by Griess assay	[PMID: 19359068]
RPMI-7951	GI50	2.3 μM	Growth inhibition of human RPMI-7951 cells measured after 72 hrs by microplate reader analysis	[PMID: 32172081]
SVR	GI50	1.8 μM	Cytotoxicity against mouse SVR cells assessed as cell growth inhibition by anti-angiogenisis screening assay	[PMID: 32172081]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inducer
CAS Number	131359-24-5
Applications	NQO1 inducer
Formula	C₁₇H₁₄O₃
Molecular Weight	266.29
SMILES	O=C(/C=C/C1=CC=CC=C1O)/C=C/C2=CC=CC=C2O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.