2-Methoxyestradiol

Catalog No.: A10012

Apoptotic, antiproliferative and antiangiogenic agent

2-Methoxyestradiol

2-Methoxyestradiol Chemical Structure

CAS NO. 362-07-2

2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $40.00

Special Price $32.00

50 mg

Regular Price: $100.00

Special Price $80.00

100 mg

Regular Price: $170.00

Special Price $136.00

200 mg

Regular Price: $300.00

Special Price $240.00

10mM * 1mL in DMSO
$71.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation.
Targets
HIF-2α (Rat aortic smooth muscle A-10 cells) Microtubule Associated (Cell-free assay) HIF-1α (MDA-MB-231 cells)
In vitro DMSO 60 mg/mL (198.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.07 mL 165.34 mL 330.69 mL
0.5 mM 6.61 mL 33.07 mL 66.14 mL
1 mM 3.31 mL 16.53 mL 33.07 mL
5 mM 0.66 mL 3.31 mL 6.61 mL

*The above data is based on the productmolecular weight 302.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10012
Actions No
M. Wt 302.4
Formula C19H26O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 362-07-2
Synonyms 2-ME2
SMILES [H][[email protected]@]12CC[[email protected]](O)[[email protected]@]1(C)CC[[email protected]]1([H])C3=C(CC[[email protected]@]21[H])C=C(O)C(OC)=C3

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