2-Methoxyestradiol

Name: 2-Methoxyestradiol
Brand: Adooq Bioscience
SKU: A10012
Rating: 100 (268 reviews)

Catalog No.: A10012

Apoptotic, antiproliferative and antiangiogenic agent

2-Methoxyestradiol Chemical Structure

CAS NO. 362-07-2

2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation.

Availability: In stock

Package	Price	Qty
10 mg	$30.00
50 mg	$45.00
100 mg	$65.00
200 mg	$120.00
10mM * 1mL in DMSO	$71.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Biological Activity

Targets

HIF-2α (Rat aortic smooth muscle A-10 cells)	Microtubule Associated (Cell-free assay)	HIF-1α (MDA-MB-231 cells)

Solubility *

In vitro (25°C)	DMSO	55 mg/mL (181.87 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2%DMSO+30%PEG300+5%Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.07 mL	165.34 mL	330.69 mL
0.5 mM	6.61 mL	33.07 mL	66.14 mL
1 mM	3.31 mL	16.53 mL	33.07 mL
5 mM	0.66 mL	3.31 mL	6.61 mL

*The above data is based on the productmolecular weight 302.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10012
CAS No.	362-07-2
Formula	C19H26O3
M. Wt	302.4
Purity	>98%
Synonyms	2-ME2
SMILES	[H][[email protected]@]12CC[[email protected]](O)[[email protected]@]1(C)CC[[email protected]]1([H])C3=C(CC[[email protected]@]21[H])C=C(O)C(OC)=C3
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.