Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order

2-Methoxyestradiol

Catalog No.: A10012

Apoptotic, antiproliferative and antiangiogenic agent

2-Methoxyestradiol

2-Methoxyestradiol Chemical Structure

CAS NO. 362-07-2

2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation.

Availability: In stock

Package Price Qty
10 mg
$30.00
50 mg
$45.00
100 mg
$65.00
200 mg
$120.00
10mM * 1mL in DMSO
$71.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation.
Targets
HIF-2α (Rat aortic smooth muscle A-10 cells) Microtubule Associated (Cell-free assay) HIF-1α (MDA-MB-231 cells)
In vitro (25°C) DMSO 55 mg/mL (181.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2%DMSO+30%PEG300+5%Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.07 mL 165.34 mL 330.69 mL
0.5 mM 6.61 mL 33.07 mL 66.14 mL
1 mM 3.31 mL 16.53 mL 33.07 mL
5 mM 0.66 mL 3.31 mL 6.61 mL

*The above data is based on the productmolecular weight 302.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10012
CAS No. 362-07-2
Formula C19H26O3
M. Wt 302.4
Purity >98%
Synonyms 2-ME2
SMILES [H][[email protected]@]12CC[[email protected]](O)[[email protected]@]1(C)CC[[email protected]]1([H])C3=C(CC[[email protected]@]21[H])C=C(O)C(OC)=C3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy 2-Methoxyestradiol | 2-Methoxyestradiol Supplier | purchase | cost | manufacturer | order | distributor | buy 362-07-2| 362-07-2 Supplier | purchase 362-07-2 | 362-07-2 cost | 362-07-2 manufacturer | order 362-07-2 | 362-07-2 distributor
Rewards