2-Methylcitric acid is an endogenous metabolite involved in the 2-methylcitric acid cycle. Its accumulation is associated with methylmalonic and propionic acidemias, making it a valuable marker metabolite for these conditions. Additionally, 2-methylcitric acid has been shown to significantly inhibit ADP-stimulated and uncoupled respiration in mitochondria when supported by glutamate, highlighting its potential utility in metabolic research.
2-Methylcitric acid is an endogenous metabolite involved in the 2-methylcitric acid cycle. Its accumulation is associated with methylmalonic and propionic acidemias, making it a valuable marker metabolite for these conditions. Additionally, 2-methylcitric acid has been shown to significantly inhibit ADP-stimulated and uncoupled respiration in mitochondria when supported by glutamate, highlighting its potential utility in metabolic research.
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