2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog that selectively targets key metabolic pathways involving purine metabolism. This compound exhibits notable anti-inflammatory properties and serves as a potential endogenous inhibitor of poly(ADP-ribose) polymerase (PARP). Its cytoprotective effects are attributed to the inhibition of PARP activity, which prevents peroxynitrite-induced mitochondrial depolarization and subsequent oxidative stress. Additionally, hypoxanthine analogs have applications in research related to cellular responses to hypoxia.
2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog that selectively targets key metabolic pathways involving purine metabolism. This compound exhibits notable anti-inflammatory properties and serves as a potential endogenous inhibitor of poly(ADP-ribose) polymerase (PARP). Its cytoprotective effects are attributed to the inhibition of PARP activity, which prevents peroxynitrite-induced mitochondrial depolarization and subsequent oxidative stress. Additionally, hypoxanthine analogs have applications in research related to cellular responses to hypoxia.
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