Fig. 1 · Structure
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2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite
Hypoxanthine Analog
2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog that selectively targets key metabolic pathways involving purine metabolism. This compound exhibits notable anti-inflammatory properties and serves as a potential endogenous inhibitor of poly(ADP-ribose) polymerase (PARP). Its cytoprotective effects are attributed to the inhibition of PARP activity, which prevents peroxynitrite-induced mitochondrial depolarization and subsequent oxidative stress. Additionally, hypoxanthine analogs have applications in research related to cellular responses to hypoxia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 128219-85-2 |
| Applications | Hypoxanthine Analog |
| Formula | C41H49N6O8P |
| Molecular Weight | 784.84 |
| SMILES | COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@H]4O[C@@H](N5C=NC6=C5NC=NC6=O)[C@H](OC)[C@@H]4OP(N(C(C)C)C(C)C)OCCC#N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.