Fig. 1 · Structure
Documents & Downloads
25-Hydroxytachysterol3
VDR Agonist
25-Hydroxytachysterol3 is a potent Vitamin D receptor (VDR) agonist. This metabolite of Vitamin D3 exhibits significant inhibitory effects on the proliferation of epidermal keratinocytes and dermal fibroblasts while stimulating the expression of genes associated with differentiation and antioxidant response in keratinocytes. Additionally, it activates aryl hydrocarbon receptor (AhR), liver X receptors α/β (LXR α/β), and peroxisome proliferator-activated receptor γ (PPARγ), promoting the expression of CYP24A1. These characteristics make it valuable for research in skin biology and related therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 39932-44-0 |
| Applications | VDR Agonist |
| Formula | C27H44O2 |
| Molecular Weight | 400.64 |
| SMILES | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])C(/C=C/C3=C(CC[C@@H](C3)O)C)=CCC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.