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(2S,3S,11bR)-Dihydrotetrabenazine

Name: (2S,3S,11bR)-Dihydrotetrabenazine
Brand: Adooq Bioscience
SKU: A67470
Availability: OutOfStock

Cat. No. A67470 CAS 862377-27-3

VMAT2 Inhibitor

(2S,3S,11bR)-Dihydrotetrabenazine is a selective inhibitor of the vesicular monoamine transporter 2 (VMAT2), exhibiting a Ki value of 593 nM. This compound disrupts the vesicular transport of monoamine neurotransmitters, including dopamine and serotonin, leading to decreased synaptic release of these neurotransmitters. (2S,3S,11bR)-Dihydrotetrabenazine is valuable for research into Huntington's chorea and other hyperkinetic disorders, providing insights into potential therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	862377-27-3
Applications	VMAT2 Inhibitor
Formula	C₁₉H₂₉NO₃
Molecular Weight	319.44
Synonyms	(2S,3S,11bR)-DHTBZ
SMILES	COC1=C(OC)C=C2CCN(C[C@@H]([C@H](C3)O)CC(C)C)[C@@]3([H])C2=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.