3,6-DMAD dihydrochloride

Catalog No.: A54724
IRE1α-XBP1s Inhibitor
3,6-DMAD dihydrochloride is a potent inhibitor of the IRE1α-XBP1s signaling pathway, specifically targeting IRE1α oligomerization and endoribonuclease (RNase) activity. This compound has been shown to promote IL-6 secretion, implicating its role in inflammatory responses. 3,6-DMAD dihydrochloride is a valuable tool for cancer research, particularly in studies focusing on cellular stress responses and their implications in tumor biology.
Grouped product items
Size Price Stock Qty
25mg
$1,275.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description3,6-DMAD dihydrochloride is a potent inhibitor of the IRE1α-XBP1s signaling pathway, specifically targeting IRE1α oligomerization and endoribonuclease (RNase) activity. This compound has been shown to promote IL-6 secretion, implicating its role in inflammatory responses. 3,6-DMAD dihydrochloride is a valuable tool for cancer research, particularly in studies focusing on cellular stress responses and their implications in tumor biology.
Product Information
Catalog NumA54724
FormulaC22H33Cl2N5
Molecular Weight438.44
CAS Number2226511-77-7
SMILESCN(C)CCCNC1=C2C=CC(N(C)C)=CC2=NC3=C1C=CC(N(C)C)=C3.Cl.Cl
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