3'-Azido-3'-deoxy-5-fluorouridine is a purine nucleoside analogue known for its potent antitumor activity, specifically targeting indolent lymphoid malignancies. Its biological activity is primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. In addition to its therapeutic potential, 3'-Azido-3'-deoxy-5-fluorouridine serves as a versatile click chemistry reagent capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, facilitating the functionalization of biological molecules.
3'-Azido-3'-deoxy-5-fluorouridine is a purine nucleoside analogue known for its potent antitumor activity, specifically targeting indolent lymphoid malignancies. Its biological activity is primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. In addition to its therapeutic potential, 3'-Azido-3'-deoxy-5-fluorouridine serves as a versatile click chemistry reagent capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, facilitating the functionalization of biological molecules.
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