Fig. 1 · Structure
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3-Hydroxycoumarin
Cat. No.
A76423
CAS
939-19-5
Tyrosinase/LOX Inhibitor
3-Hydroxycoumarin is a potent inhibitor of tyrosinase and lipoxygenase, exhibiting an IC50 of 26 μM against recombinant human tyrosinase and a Ki of 3.39 μM. It also demonstrates effective inhibition of lipoxygenase with an IC50 of 9.5 μM. Additionally, 3-Hydroxycoumarin displays significant DPPH free radical scavenging activity (IC50 = 31.2 μM) and offers photoprotective benefits for sea urchin zygotes and embryos, making it a valuable reagent for research in enzymatic inhibition and oxidative stress studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 939-19-5 |
| Applications | Tyrosinase/LOX Inhibitor |
| Formula | C9H6O3 |
| Molecular Weight | 162.14 |
| SMILES | O=C1C(O)=CC2=CC=CC=C2O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.