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3'-NH-Tr-2',3'-DMF-ddA- 5'-CE-Phosphoramidite

Nucleoside Antimetabolite/Analog

3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite is a nucleoside antimetabolite that serves as an adenine nucleotide monomer precursor in the solid-phase synthesis of oligonucleotides. This compound features trityl (Tr), cyanoethyl (CE), and dimethylformamidine (DMF) protecting groups, making it ideal for producing modified oligonucleotides, including those with specific DNA chain end modifications. Applications include oligonucleotide synthesis, probe design, and chain-termination sequencing, where it plays a crucial role in enhancing the specificity and performance of nucleic acid-based assays.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1644649-86-4
Applications	Nucleoside Antimetabolite/Analog
Formula	C₄₁H₅₀N₉O₃P
Molecular Weight	747.87
SMILES	CC(C)N(C(C)C)P(OCCC#N)OC[C@H]1O[C@@H](N2C3=NC=NC(/N=C/N(C)C)=C3N=C2)C[C@@H]1NC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.