Fig. 1 · Structure
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4-Hydroxyatomoxetine
Noradrenalin Re-uptake Inhibitor
4-Hydroxyatomoxetine acts as a potent noradrenaline re-uptake inhibitor, primarily targeting the norepinephrine transporter. As an active metabolite of Atomoxetine, it exhibits selective inhibition with Ki values of 5 nM for the norepinephrine transporter, 77 nM for the serotonin transporter, and 1451 nM for the dopamine transporter. This compound is utilized in research applications focused on neuropharmacology and the modulation of noradrenergic signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 435293-66-6 |
| Applications | Noradrenalin Re-uptake Inhibitor |
| Formula | C17H21NO2 |
| Molecular Weight | 271.35 |
| SMILES | OC1=CC=C(O[C@@H](C2=CC=CC=C2)CCNC)C(C)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.