4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid

Catalog No.: A43310
ADC Linker
4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the conjugation of therapeutic agents to antibodies, promoting targeted delivery and enhanced efficacy in cancer treatment. Its unique disulfide bond allows for selective cleavage within the tumor environment, releasing the cytotoxic drug while minimizing systemic toxicity.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the conjugation of therapeutic agents to antibodies, promoting targeted delivery and enhanced efficacy in cancer treatment. Its unique disulfide bond allows for selective cleavage within the tumor environment, releasing the cytotoxic drug while minimizing systemic toxicity.
Product Information
Catalog NumA43310
FormulaC11H15NO2S2
Molecular Weight257.37
CAS Number1537891-69-2
SMILESOC(CCC(C)(C)SSC1=CC=CC=N1)=O
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