Fig. 1 · Structure
Documents & Downloads
5,6-Epoxyeicosatrienoic acid
Metabolite
5,6-Epoxyeicosatrienoic acid (5,6-EET) is a racemic metabolite derived from arachidonic acid through cytochrome P450 enzyme activity. This compound plays a crucial role in calcium mobilization and hormone secretion in neuroendocrine cells, such as those in the anterior pituitary and pancreatic islets. Additionally, 5,6-EET serves as an inhibitor of T-type voltage-gated calcium channels (Cav3), particularly affecting isoforms Cav3.1 and Cav3.2, which can decrease vasoconstriction in isolated mouse mesenteric arteries. It is also a substrate for COX-1 and COX-2, highlighting its relevance in inflammatory pathways.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 87173-80-6 |
| Applications | Metabolite |
| Formula | C20H32O3 |
| Molecular Weight | 320.47 |
| Synonyms | 5,6-EET; (±)5,6-EpETrE |
| SMILES | OC(CCC[C@H]1[C@H](O1)C/C=C\C/C=C\C/C=C\CCCCC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.