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5’-Azido-5’-deoxy-2’-O-(2-methoxyethyl)-5-methyluridine

Purine Nucleoside Analog

5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)-5-methyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound functions as a click chemistry reagent due to its azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. It can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with entities possessing DBCO or BCN groups, making it a versatile tool for chemical biological research.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2095417-42-6
Applications	Purine Nucleoside Analog
Formula	C₁₃H₁₉N₅O₆
Molecular Weight	341.32
SMILES	O=C(C(C)=C1)NC(N1[C@@H]2O[C@H](CN=[N+]=[N-])[C@@H](O)[C@H]2OCCOC)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.