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5’-Azido-5’-deoxy-2’-O-methyluridine

Purine Nucleoside Analog

5’-Azido-5’-deoxy-2'-O-methyluridine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and induction of apoptosis. Additionally, this compound functions as a versatile click chemistry reagent, featuring an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This unique combination of biological activity and reactivity makes it valuable for various research applications in chemical biology.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	194034-68-9
Applications	Purine Nucleoside Analog
Formula	C₉H₁₁N₅O₅
Molecular Weight	269.21
SMILES	O[C@H]1[C@@H](OC)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1N=[N+]=[N-]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.