Fig. 1 · Structure
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5-Fluoroorotic acid monohydrate
Antimalarial Agent
5-Fluoroorotic acid monohydrate is a monohydrate salt derivative of 5-Fluoroorotic acid, primarily acting as an inhibitor of thymidylate synthase. This compound functions as a selective agent in yeast molecular genetics and demonstrates notable antimalarial activity. Its ability to interfere with nucleotide metabolism makes it a valuable tool in studying parasite biology and developing antimalarial therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 220141-70-8 |
| Applications | Antimalarial Agent |
| Formula | C5H5FN2O5 |
| Molecular Weight | 192.10 |
| Synonyms | 5-Fluorouracil-6-carboxylic acid Mono(hydrate); 5-FOA; 5-fluoro OA |
| SMILES | O=C(C(NC1=O)=C(F)C(N1)=O)O.[H]O[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.