Fig. 1 · Structure
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5-Hydroxymethyl-2'-deoxyuridine
Nucleoside Analog
5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog that serves as an effective inhibitor of DNA replication in various human leukemia cell lines, exhibiting IC50 values ranging from 1.7 to 5.8 μM. This compound has been shown to extend the survival of mice with L1210 leukemia, demonstrating its potential in cancer treatment research. Its unique properties make it a valuable tool for investigating mechanisms of cell replication and the biology of leukemia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 5116-24-5 |
| Applications | Nucleoside Analog |
| Formula | C10H14N2O6 |
| Molecular Weight | 258.23 |
| SMILES | O[C@H]1C[C@H](N2C(NC(C(CO)=C2)=O)=O)O[C@@H]1CO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.