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5'-O-DMT-2-thio-2'-dU-3'-phosphoramidite

Purine Nucleoside Analog

5'-O-DMT-2-thio-2'-dU-3'-phosphoramidite is a purine nucleoside analog that acts as a potent inhibitor of DNA synthesis. It exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inducing apoptosis and disrupting nucleotide incorporation during DNA replication. This compound is essential for research into cancer therapeutics and the development of novel DNA-targeting strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	152753-94-1
Applications	Purine Nucleoside Analog
Formula	C₃₉H₄₇N₄O₇PS
Molecular Weight	746.85
SMILES	CC(C)N(C(C)C)P(OCCC#N)O[C@H]1C[C@H](N2C(NC(C=C2)=O)=S)O[C@@H]1COC(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.