Fig. 1 · Structure
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5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite
Purine Nucleoside Analog
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite is a purine nucleoside analog that inhibits DNA synthesis and promotes apoptosis, demonstrating significant antitumor activity. This reagent is primarily employed in the synthesis of modified oligonucleotides for research in cancer biology and therapeutic development targeting indolent lymphoid malignancies. Its ability to serve as an effective building block facilitates advanced studies in molecular genetics and nucleic acid research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 142808-44-4 |
| Applications | Purine Nucleoside Analog |
| Formula | C46H50F2N5O8P |
| Molecular Weight | 869.89 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@H]1C(F)(F)[C@H](N2C(N=C(NC(C3=CC=CC=C3)=O)C=C2)=O)O[C@@H]1COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.