Fig. 1 · Structure
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5J-4
CRAC Inhibit
5J-4 is a potent inhibitor of calcium release-activated calcium (CRAC) channels. This compound effectively reduces the infiltration of mononuclear cells, particularly CD4+ T cells, into the central nervous system. Research indicates that 5J-4 alleviates symptoms and delays the onset of experimental autoimmune encephalomyelitis (EAE) in mouse models, making it a valuable tool for studying inflammation and autoimmune disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 827001-82-1 |
| Applications | CRAC Inhibit |
| Formula | C16H12N2O3S |
| Molecular Weight | 312.35 |
| SMILES | O=C(C1=CC=CO1)NC(NC2=CC=CC3=C2C=CC(O)=C3)=S |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.