Fig. 1 · Structure
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6,7-Dihydroxy-4-coumarinylacetic acid
ALR2 Inhibitor
6,7-Dihydroxy-4-coumarinylacetic acid is a selective inhibitor of aldose reductase type 2 (ALR2). This compound demonstrates potent inhibition of ALR2 with an IC50 of 9.6 μM, while also affecting sorbitol dehydrogenase (SDH) and ALR1 with IC50 values of 288 μM and 66.3 μM, respectively. It effectively suppresses the accumulation of galactitol, making it a valuable tool for studying diabetic complications and aldose reductase-mediated pathways in biochemical research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 88404-14-2 |
| Applications | ALR2 Inhibitor |
| Formula | C11H8O6 |
| Molecular Weight | 236.18 |
| SMILES | O=C(O)CC(C1=CC(O)=C(O)C=C1O2)=CC2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.