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- Cat. No.
- A11790
Fidarestat (SNK-860)
Synonyms: SNK 860
Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.
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- Cat. No.
- A13083
Tolrestat
Synonyms: AY-27773
Tolrestat is an aldose reductase inhibitor[1] which was approved for the control of certain diabetic complications.
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- Cat. No.
- A13523
Ranirestat
Synonyms: AS-3201; SX-3201
Ranirestat is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy.
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- Cat. No.
- A20868
Imirestat
Synonyms: AL 1576; Alcon 1576; HOE 843
Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.
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- Cat. No.
- A20976
Aldose reductase-IN-1
Aldose reductase-IN-1 is a inhibitor of aldose reductase with IC50 of 28.9 pM. IC50 value: 28.9 pM Target: aldose reductase Detailed information please refer to WO2014113380 A1 and US20130225592.
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- Cat. No.
- A21112
Risarestat
Synonyms: CT 112
Risarestat (CT-112), an aldose reductase inhibitor, is developed for the treatment of diabetic complications
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- Cat. No.
- A22132
Statil
Synonyms: Ponalrestat
Ponalrestat, also known as MK-538, is an aldose reductase inhibitor.
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- Cat. No.
- A22588
AT-007
AT-007 is an orally active central nervous system (CNS) penetrant Aldose Reductase inhibitor for treatment of Galactosemia with an IC50 value of 100 pM. AT-007 reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.
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- Cat. No.
- A25606
ALR2-IN-9
ALR2-IN-9 is a potent inhibitor of aldose reductase (ALR2), exhibiting an IC50 of 21.8 nM. It demonstrates strong antioxidant properties, evidenced by an EC50 of 2.8 μM in DPPH radical scavenging assays. By directly interacting with reactive oxygen species (ROS) and reactive nitrogen species (RNS), ALR2-IN-9 disrupts free radical chain reactions and enhances the functions of catalase (CAT) and superoxide dismutase (SOD). Furthermore, it modulates the PI3K/Akt/Nrf2 signaling pathway to reduce hyperglycemia-induced mitochondrial superoxide production in vitro and alleviates oxidative stress in vivo. ALR2-IN-9 also extends the lifespan of C. elegans through the regulation of stress response genes, making it a valuable candidate for research into diabetic complications and anti-aging therapies.
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- Cat. No.
- A31036
WJ-39
WJ-39 is a potent orally active inhibitor of aldose reductase (AR), demonstrating significant therapeutic potential. This compound has been shown to mitigate tubular damage in diabetic nephropathy models by activating the PINK1/Parkin signaling pathway, thereby promoting mitophagy and reducing apoptosis. WJ-39 serves as a valuable tool for studying diabetic complications and the underlying mechanisms of kidney injury.
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- Cat. No.
- A31906
APPA
APPA is an aldose reductase inhibitor that functions by disrupting the polyol pathway, thereby preventing apoptosis associated with diabetic conditions. In preclinical studies, APPA has demonstrated efficacy in alleviating symptoms related to Streptozotocin-induced diabetes in rat models. This compound shows promise for research applications in diabetic nephropathy (DN), offering insights into potential therapeutic strategies.
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- Cat. No.
- A38949
Danshenol A
Danshenol A is a potent aldose reductase inhibitor, exhibiting an IC50 of 0.1 μM. This abietane-type diterpenoid demonstrates protective effects on endothelial cells against oxidative stress through direct scavenging of reactive oxygen species (ROS). Additionally, Danshenol A possesses notable anti-inflammatory and antitumor properties, making it a valuable compound for research focused on atherosclerosis and related pathologies.
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- Cat. No.
- A43579
Cemtirestat
Synonyms: CMTI
Cemtirestat is a carboxymethylated thiatriazinoindole that functions as an inhibitor of aldose reductase (ALR2). It demonstrates potent inhibition of rat ocular lens ALR2, with an IC50 of 0.116 μM, and displays a significant 302-fold selectivity for rat kidney ALR1. This compound is primarily utilized in research focused on advanced diabetic complications.
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- Cat. No.
- A43585
Zopolrestat
Synonyms: CP73850
Zopolrestat is a potent inhibitor of aldose reductase (AR) with an IC50 of 3.1 nM. This compound is primarily utilized in research focused on diabetic complications, providing insights into the metabolic pathways involved in diabetes-related disorders. Its application extends to studying the therapeutic potential in mitigating diabetic neuropathy and retinopathy, making it a valuable tool in diabetes research.
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- Cat. No.
- A43586
Ganoderic acid C2
Ganoderic acid C2 is a bioactive triterpenoid that functions as an aldose reductase inhibitor, displaying an IC50 of 43.8 µM. This compound exhibits potential anti-tumor activity along with antihistamine and anti-aging properties. Its cytotoxic effects make Ganoderic acid C2 a valuable reagent for research in fields such as cancer biology and metabolic disorders.
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- Cat. No.
- A43588
6-Hydroxyluteolin
6-Hydroxyluteolin is a flavonoid identified as an aldose reductase inhibitor. It demonstrates potential antidiabetic activity by reducing the conversion of glucose to sorbitol, thereby mitigating osmotic and oxidative stress in diabetic tissues. This compound is useful in research applications focused on diabetes-related complications and metabolic disorders.
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- Cat. No.
- A43589
Zenarestat
Zenarestat is a potent and orally active inhibitor of aldose reductase, an enzyme involved in the polyol pathway. This compound demonstrates significant biological activity by improving symptoms of diabetic peripheral neuropathy in preclinical models, specifically in Zucker diabetic fatty rats. Zenarestat may serve as a valuable tool for research into diabetic complications and the modulation of glucose-related metabolic disorders.
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- Cat. No.
- A43590
Exisulind
Exisulind is an aldose reductase inhibitor with an IC50 of 367 nM in vitro. As an inactive metabolite of sulindac, it may play a role in mitigating complications associated with type 2 diabetes through its pharmacological effects. This compound is valuable for research focused on metabolic disorders and the management of diabetes-related complications.
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- Cat. No.
- A43591
Lidorestat
Synonyms: IDD-676
Lidorestat is a potent and selective aldose reductase inhibitor, exhibiting an IC50 of 5 nM. This compound is primarily used in research focused on chronic complications associated with diabetes. It has demonstrated efficacy in enhancing nerve conduction and reducing the formation of cataracts, making it valuable for studies relating to diabetic neuropathy and cataractogenesis.
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- Cat. No.
- A43592
MK204
MK204 is an aldose reductase (AR) inhibitor that plays a significant role in diabetes research. By inhibiting AR, MK204 can modulate the polyol pathway, potentially reducing complications associated with diabetes. This compound is valuable for investigating the mechanisms of diabetic pathophysiology and exploring therapeutic approaches for managing diabetes-related conditions.
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- Cat. No.
- A43594
Ganoderic acid C6
Ganoderic acid C6 functions as an aldose reductase inhibitor, effectively modulating glucose metabolism. This compound is important for research aimed at understanding diabetic complications and oxidative stress management. Its potential to influence pathways associated with diabetic neuropathy and retinopathy makes it a valuable reagent for investigating therapeutic strategies in metabolic disorders.
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- Cat. No.
- A43595
Alrestatin
Synonyms: AY-22284
Alrestatin is a selective inhibitor of aldose reductase, an enzyme implicated in the development of diabetic complications such as diabetic neuropathy. By inhibiting this enzyme, Alrestatin plays a role in modulating glucose metabolism and reducing oxidative stress. This compound is useful for research focused on diabetes-related pathologies and potential therapeutic interventions.
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- Cat. No.
- A43600
Cornoside
Cornoside is a phenolic glycoside that acts as an aldose reductase inhibitor, exhibiting an IC50 of 150 μM against rat lens aldose reductase. This compound is valuable in research focused on diabetic complications and oxidative stress-related conditions. Its ability to modulate aldose reductase activity makes it a significant tool for studying pathways involved in polyol metabolism.
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