6-Iodonordihydrocapsaicin

Catalog No.: A68799
TRPV1 Antagonist
6-Iodonordihydrocapsaicin is a selective antagonist of the TRPV1 receptor. It effectively inhibits TRPV1-mediated responses, such as capsaicin-induced ion currents in dorsal root ganglion neurons and the distension-induced firing of jejunal spinal afferent fibers in murine models. This compound is valuable for research focused on visceral pain mechanisms and the exploration of anxiety disorders.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description6-Iodonordihydrocapsaicin is a selective antagonist of the TRPV1 receptor. It effectively inhibits TRPV1-mediated responses, such as capsaicin-induced ion currents in dorsal root ganglion neurons and the distension-induced firing of jejunal spinal afferent fibers in murine models. This compound is valuable for research focused on visceral pain mechanisms and the exploration of anxiety disorders.
Product Information
Catalog NumA68799
FormulaC17H26INO3
Molecular Weight419.30
CAS Number859171-97-4
SMILESCCCCCCCCC(NCC1=CC(OC)=C(O)C=C1I)=O
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