Fig. 1 · Structure
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7-Benzyloxy-4-(trifluoromethyl)coumarin
Coumarin Substrate
7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) is a coumarin-based fluorescent substrate utilized for the evaluation of cytochrome P450 enzymes CYP1A2 and CYP3A4. Upon metabolism, 7-BFC is converted into 7-hydroxy-4-trifluoromethylcoumarin (HFC). This compound is valuable for conducting rapid screening of CYP isoform metabolism and inhibition assays in pharmacological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 220001-53-6 |
| Applications | Coumarin Substrate |
| Formula | C17H11F3O3 |
| Molecular Weight | 320.26 |
| Synonyms | 7-BFC |
| SMILES | C1=CC=C(C=C1)COC2=CC3=C(C=C2)C(=CC(=O)O3)C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.